Voltammetric Behaviour of Metronidazole at Mercury Electrodes
نویسندگان
چکیده
Metronidazol é o fármaco mais importante do grupo de 5-nitroimidazoles, possuindo toxicidade contra microrganismos anaeróbicos, sendo a molécula de DNA o principal alvo de sua ação biológica. O mecanismo de ação do metronidazol depende do processo de redução do grupo nitro e, em meio ácido, a redução é pH-dependente envolvendo quatro elétrons na completa redução ao derivado hidroxilamínico. Em meio aprótico a redução do metronidazole acontece em duas etapas: a primeira envolvendo um elétron para formar o radical nitro e a segunda etapa envolve mais três elétrons até a formação da hidroxilamina. Neste artigo o mecanismo de redução do metronidazol foi estudado utilizando as técnicas voltamétricas: polarografia d.c. e pulso diferencial, voltametria cíclica usando o eletrodo gota de mercúrio como eletrodo de trabalho.
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